Diphenamid (N,N-dimethylacetamide) 
Labeled diphenamid was administered to male rats (Purdue-Wistar 
strain) orally, intraperitoneally, and subcutaneously. Half-lives were 
found to be 245, 235, and 210 minutes, respectively. Demethylation of 
diphenamid was found to be extensive; nordiphenamid was demethylated to 
a lesser extent. Analysis of urine showed the presence of nordiphenamid, 
diphenylacetamide, nordiphenamid N-glucuronide, N-methyl-N-hydroxymethyl 
diphenylacetamide O-glucuronide, p-hydroxydiphenamid, and p-hydroxy- 
nordiphenamid. The latter two are excreted as glucuronides and/or 
sulfates (McMahon and Sullivan, 1965). 
9 LH; Q CH 
-C=N -f~ 3 
C CH; — Hot _-¢H © NSCH, 
Diphenamid Glucuronide/ 
v 
or Sulfate 
Oo 
ge 
Xp SH 
N-Glucuronide Glucuronide/ 
or Sulfate 
97 
