Heptachlor 
Heptachlor was rapidly metabolized by houseflies to heptachlor 
epoxide (Perry et al., 1958b). No other metabolite was found. Simi- 
larly, the only metabolite recovered from plants (Gannon and Decker, 
1958a) or from soil (Gannon and Bigger, 1958a; Young and Rawlins, 1958; 
Barthel et al., 1960; Murphy and Barthel, 1960; Wilkinson et al., 1964) 
was heptachlor epoxide. In aqueous suspensions of heptachlor, 1l-hydroxy- 
chlordene has also been found (Bowman et al., 1964). 
When heptachlor was fed to rats (Radomski and Davidow, 1953), dogs 
(Davidow and Radomski, 1953a), and cows (Davidow et al., 1953b) or when 
cows were grazed on heptachlor treated pasture (Stoddard et al., 1954; 
Ely et al., 1955; Bache et al., 1960; Rusoff et al., 1962, 1963), only 
heptachlor epoxide was found in the tissues of these animals and in the 
cows’ milk. Studies have shown that epoxidation of heptachlor to hepta- 
chlor epoxide occurred in the microsomal fraction of the liver, at least 
in rats (Wong and Terriere, 1965). 

cli 
CG 
Cl 
Insects | | 
Mammals 
Plants Heptachlor UV 
Soil Microorganisms 
| 
cl ie Cl OH 
a 4H 
Heptachlor Epoxide 1-Hydroxychlordene 
117 
