Maleic Hydrazide (MH, 6-hydroxy-3(2H) pyridazinone) 
Ultraviolet studies indicated that maleic hydrazide exists as 
the hydroxy pyridazinone (Miller and White, 1956). 
Using cl4_1abeled maleic hydrazide and glucose, studies have shown 
mn 
that the Bp-glucoside is formed. No other metabolites have been 
demonstrated (Weller et al., 1957; Towers et al., 1958). 
+ CgH} 0, > B-Glucoside 

Maleic 
Hydrazide 
Metasystox - mixture of 
0,0-Dimethyl-O-ethylmercaptoethyl thiophosphate (TI) 
0,0-Dimethyl-S-ethylmercaptoethyl phosphorothiolate (IT) 
Metabolism of metasystox is similar to that of systox. Some studies 
have shown that metasystox also undergoes a non-enzymatic self alkylation. 
There is some indication that systox may undergo the same reaction 
(Niesen et al., 1963). 
ange Nag Mer cea Ne le leas 
CH, 
II 
io) 
© 
ope, 
i 
~S-CHy -CHy-S-CH)-CH3 + CH30-P-S-CHp -CHy~$~-CHy -CHy 
; OCH H3 
CH,0-P 
0 
124 
