Thiometon (Bayer 23655) (0,0-Dimethyl S-isopropyl-2-sulfinylethyl 
phosphorothiolate) 
Thiometon is similar to demeton S and its metabolism was also similar. 
Thiometon penetrated and translocated rapidly into citrus and rice plants. 
After penetration, thiometon underwent oxidization to the sulfone and 
hydrolysis to the phosphoric and dimethyl phosphoric acids (Tomizawa, 1963). 
, CHRD nog 4 
(CH30) 9 -P-S-bH-CH> -S-CH -CH3 (CH30) 2 -P-S-CH-CH9 -~5-CH -CH3 
0 
Thiometon Thiometon Sulfone 
NS cy fm 
(CH30) 9 -P-OH 
Dimethyl Phosphoric 
Acid 
! 
H3P0,, 
Phosphoric Acid 
Tillam (S-Propyl-n-butylethylthiocarbamate) 
Plant cells readily degrade Tillam-cl4 and give rise to cl4g,. In 
rats, tillam is rapidly eliminated. While excretion via the urine 
averages about 23%, feces samples were low, indicating that tillam is 
easily absorbed from the gastrointestinal tract and rapidly oxidized. 
Feeding studies with rats with labeled tillam gave rise to labeled amino 
acids, urea, and a conjugate which has not been identified (Fang et al., 
1962, 1964a). 
157 
