: CoHs , Unchanged 
CH3-CH -CH)-S—C NC oe 
CyHy Lungs and 
Kidneys 
Tillam 
[0] 
CHa Ply seis ae Sul fone 
Kidneys 
as conjugate Transthiolation 
Oxidation Protein, Amino Acids 
CH, -CH» ~CH -OH —_—_-—» 3 Carbon Metabolic Pool 
CO, + H,0 
TIMID (Tetramethyl thuiram disulfide, Thiram) (Bis[dimethylthiocarbamoy] ] 
disulfide) 
TMTD is known to inhibit fermentation of glucose, fructose-1,6-di- 
phosphate, and glyceraldehyde-3-phosphate and to inhibit triosephosphate 
dehydrogenase (Sisler and Cox, 1955). MTD reacted with thiols by a 
radical exchange mechanism. The final products are the corresponding 
disulfide of the parent thiol and dimethyldithiocarbamate (Owens and 
Rubinstein, 1964; Saville, 1960). (See also Dithiocarbamates and TTD.) 
CH3 ois CHa, 
N-C-S-S-C-N +  2GSH~—~2 N-C-SH 
cH’ ll ll Soy cH’ tl 
3 S S 3 3 S 
pH=5 + 
CS, G-S-S-G 
158 
