Trithion (0,0-Diethyl S(p-chlorophenyithio)methyl phosphorodithioate) 
The oxidative metabolism of trithion was studied on field-growing 
lettuce. Samples were removed at various times after spraying and 
analyzed. Results indicated that the principal route of oxidation involved 
thioether oxidation to form the sulfoxide and then the sulfone. This was 
followed by phosphorothionate oxidation to form the thiolphosphate sulfone 
(Coffin, 1964a). 
S) 
(C5H50) 2 -b-s-CH, -s-{ )-cl 
Trithion 
S 0 
i 
) 
l r ! 
(CpHis0) 9-P-S~CHiy-S-(~ Cl ices (CpH50) y-P-S-CH)-8-)~Cl 
1 
if 
(C5H50) 3 -P-S-CH, i 
0 0 
lt it 
-< )-cl —_——oS (CjH50) 9-P-S-CHy “(pel 
0 
=W=O 
io) 
Trolene (Ronnel) (0,0-Dimethyl O-{2,4,5-trichlorophenyl] phosphoro- 
thioate) 
After administration of radioactive trolene, the highest levels of 
trolene and its derivatives in all tissues were reached after 12 hours. 
Equilibration was reached after about 12 days. Residues persisting 7 
days after oral administration were similar to trolene and its oxygen 
analog. The tissues in order of decreasing persistence of trolene and 
metabolites were those of: liver, kidney, spleen, subcutaneous and 
mesenteric fat, heart, brain. 
167 
