(Stromme, 1965a). The greater part of this radioactivity was liberated 
by the addition of glutathione and the product was identified as diethyl- 
dithiocarbamate (Stromme, 1964, 1965b). In vitro studies also showed that 
TID reacted with glutathione (Johnston, 1953). 
Using rats, 535-1abeled TTD was administered intraperitoneally. The 
unchanged material was never detected in plasma, liver, or urine. Sulfate, 
CS7, the S-glucuronide of diethyldithiocarbamate, and traces of the free 
thiol were found in the urine. In addition to these metabolites, there 
were protein bound mixed disulfides in the plasma and liver (Strome, 
1965a, b). 
CH3-CHy 3 5 CH) -CH3 
~y-O-s-s-U-n 
CHy-CH, NCH, -CH3 
TTD 
CH3-CH, > 
DN-C-SH | =———>>  (CH3-CHp) 9-NH + CS2* 
CH3-CH 
Diethyldithiocarbamic + H9S 
Acid + 
0. JH S07, 
O—— CH 
CH3-CH)_ 
/N-C-S-CH CHOH 
CH3-CH 
CH——CH 
N,N-Diethylthiocarbamoyl 
1-Thio-8 -D-Glucopyranosiduronic 
Acid 
