
CEPC [2-Chloroethyl-N-(3-chlorophenyl) carbamate] 
CIPC (Chloropropham) [Isopropyl N-(3-chlorophenyl) carbamate] 
IPC (Propham) [Isopropyl N-phenylcarbamate ] 
When applied to plants, IPC was metabolized to the corresponding N-OH 
analog (91). An amidohydrolase was isolated from soybeans which hydrolyzed 
IPC (561). 
In recent studies a bacterium, Pseudomonas sp., was found in soil 
that hydrolyzed phenylcarbamate herbicides to the corresponding aniline. 
While this is a general reaction for the phenylcarbamate esters, urea 
analogs were not hydrolyzed (773, 774, 775). 
Pseudomonas striata, a flavobacterium, an agrobacterium, and an 
achromobacter were able to degrade CIPC, as demonstrated by production 
of 3-chloroaniline and subsequent liberation of chloride. An 
achromobacter and an arthrobacter were able to degrade CEPC (768). 
First order rate constants in terms of reciprocal time and heat of 
activation (H.) were derived for IPC and CIPC (211). 
TG k (day ~”) Ho 
IPC 15 4.67 x 1075 7,768 
29 8.79 x 107 
CIPC 15 4.25 x 1075 21,247 
29 2.39 x 107 
In other studies conducted with microorganisms derived from the 
activated sludge and effluent of a sedimentation basin, CIPC was hydrolyzed 
and metabolized. The phenyl ring was attacked and degraded. Metabolism 
via 4-chlorocatechol and the ketoadipic acid system was proposed (1594). 
(SEE ALSO UC-10854). 
In recent studies, rats were administered IPC intraperitoneally. 
Examination of collected urine, showed the presence of isopropyl N-p- 
hydroxyphenylcarbamate as the O-sulfate (1688). 
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