Chlordane, Chlordene, Dihydrochlordene, Dihydroheptachlor, Heptachlor 
Dihydrochlordene (4,5,6,7,8,8-hexachloro-1,2,3a,4,7,7a-hexahydro-4, 
7-methanoindene) 
Dihydrochlordene (1) was incubated with housefly and pig liver 
microsomes, nicotinamide, and NADP. Evidence indicated that two of 
the metabolites were (II) and (III). Traces of IV and V were believed 
to be present also. 
Incubation of (II) with pig liver or housefly microsomes and 
NADPH, gave rise to a diol, identical to that produced by hydroxylation 
of dihydrochlordene and believed to be IV. 
After incubation of Compound V with pig liver or housefly microsomes 
and NADPH,, the trans-diol VI was formed. Another compound, believed to 
be 2-ketodihydrochlordene, (VII) was also found, Incubation of the 
latter with added NADPH, gave rise to V (189). 
Cl 
C1 Cl 
OH 
Cl re Aa 
My II 
/ III 
ci I 
OP es 
HO 
IV Vv 
OH 
+ 
OH 0 
VI VIL 
86 

