Citicide (Polychlorinated turpentine) 
When citicide was fed to rats, a portion passed through the alimen- 
tary canal unabsorbed and was excreted in the feces. In urine, very little 
citicide was excreted; however, chloride excretion was very high. Ethereal 
sulfate and glucuronic acid excretion was also significantly higher in 
citicide-fed animals than in controls. Mercapturic acid excretion of test 
animals was not significantly different than that of controls. Since 
halogenated aromatic hydrocarbons are detoxified in the liver via ethereal 
sulfate and glucuronic acid conjugates, it is quite probable that increased 
levels of these materials indicated detoxification processes of citicide 
(837). 
No citicide was found in the body fat and liver but chloride levels 
were higher than those for controls. This indicated the storage of metab- 
olites in the body fat. None have been isolated thus far. 
Colep [0-Phenyl-O0'- (4-nitrophenyl) methylphosphonothionate ] 
! The major portion of the radioactivity after administration of colep- 
14 ; , ae ; , 
C” to rats was found in the urine within 24 hours. Liver and kidney 
contained little radioactivity after 24 hours, indicating that detoxification 
and excretion was nearly complete. No measurable activity was incorporated 
in the abdominal fat nor released as CO. (925). 
The predominant excretory conjugate in mammals fed low levels of 
phenol was phenylsulfuric acid (1508). This type of compound was probably 
the strongly acidic metabolite found in the urine. After acid hydrolysis 
of urine samples, phenol was released. 
After colep was applied to plants, the oxon analog was found in small 
amounts, The major amount of activity was apparently conjugated. Studies 
with acid and emulsin hydrolysis indicated the presence of phenyl §-glucoside 
and an a-glycoside. Another fraction contained phenyl sulfate. After acid 
hydrolysis of benzene, chloroform, and water extracts converted 75-804 of the 
radioactivity to phenol for both cotton and apple, thus showing the association 
of the radioactivity with phenol-containing materials (925). 
98 

