Banol (2-Chloro-4,5-dimethylphenyl N-methylcarbamate) 
Following subacute oral administration of banol to rats, elimination 
was essentially complete within 48 hours. Methylamine to CO» were identi- 
fied as metabolites. A number of other metabolites, including glucuronates, 
were observed but not identified (87, 836). In more recent studies 2-chloro- 
4,5—xylyl N-hydroxymethylcarbamate and 2-chloro-4,5-xylenol were identified 
after incubation of banol in a rat liver mi crosome-NADPH,, system (1112). 
Twelve day old pinto bean seedlings were placed in beakers containing 
labeled banol. Seven days later, the plants were macerated and extracted. 
Chromatography of the extracts revealed four metabolites. Although none of 
the metabolites were identified, one was characterized as a glucoside (496, 
497, 845). In other studies N-hydroxy banol was identified. Seven other 
compounds were observed but not identified (846). 
The degradation of banol by microsomes or by whole Blaberus giganteus 
fat body resulted in the formation of at least three metabolites. Studies 
indicated that one of these metabolites was N-hydroxymethyl banol (533, 
1603). In houseflies, labeled N-C!"H3 and C!"=0 gave rise to C1405: 
Hydrolysis to the corresponding phenol also occurred (1001). In the 
presence of NADPH», fly homogenates also converted banol to the N-hydroxy- 
methyl analog (1427). 
After exposure to UV (2537 A), 6 compounds were detected. Several 
unidentified compounds were also observed after treatment of bean plants 
(3). 


ve F a 
OS cH5 0H 3 “CH 3 
Plant Rat Liver OH 
Rat Liver 
Cl 
‘ -Cl 
. Microsomes 
ee ; NADPH, 
y Homogenate tae 
CH3 NADPH, re y cH, 
N-Hydroxy Banol Banol 2-Chloro-4 ,5- 
Xylenol 
Plant 
Glucuronides/or glucuronates 
46 

