Aldrin, Dieldrin, Isodrin, Endrin 
Aldrin was readily converted to dieldrin in the body of beef and dairy 
cattle, pigs, sheep, rats, and poultry (79). This change was independent of 
the mode of entry, since it occurred following oral ingestion or subcutaneous 
injection. 
When aldrin Beat was fed to male rats (847, 903), or orally injected 
into male and female rats (640), the active material excreted in feces and 
urine consisted of aldrin, dieldrin, and considerable amounts (up to 7/54 in 
feces and up to 95% in urine), of a mixture of unidentified hydrophilic 
metabolites, At a feeding level of 4.3 mcg per day, a Saturation level was 
reached after about eight weeks, Daily excretion of active material approxi- 
mated the entire activity administered daily. If injected, 16.2% of aldrin- 
cl4 and 13% of dieldrin-c!4 was excreted within four hours, via the bile into 
the intestinal canal, mainly as hydrophylic compounds (830, 1041). Recent 
studies with rat and rabbit livers showed that this epoxidation was performed 
by the microsomes (1069, 1521). 
Paper chromatography of extracts of feces and urine showed a high per- 
centage of aldrin-c!4 initially. The percentage of unchanged aldrin then de- 
creased while that of hydrophylic metabolites increased continuously for about 
twelve days; and the distribution of excreted compounds remained unchanged as 
long as aldrin was administered daily. After aldrin administration was discon- 
tinued, the relative percentage of aldrin in feces decreased and dieldrin 
increased (847, 903). Paper and thin-layer chromatography showed that two 
different compounds were in the feces; that two different compounds were in 
the urine; and that one of the compounds in feces behaved like one of those 
in the urine, Hydrolysis of the main compound from urine with alcoholic KOH 
gave a new acidic compound (903). When rabbits were given aldrin intravenously, 
hydrolysis of the metabolites gave the aldrin diol (830). 
Dieldrin was administered internally to rats as a single dose of 
20 mg/kg body weight. During the first 8 days, unchanged dieldrin was excreted 
in urine, Within the following 4 days, a product of dieldrin was excreted. 
Of the dieldrin administered, 15.7% was excreted within 14 days in the feces 
(1253). Other feeding studies with rats have also shown that dieldrin is 
metabolized to two compounds more polar than dieldrin and unstable to 
alcoholic KOH (338). On the basis of elemental analysis, mass spectra, I.R. 
and Raman spectra, the structure of compound XI was proposed (335). 
When labeled dieldrin was administered to a rabbit via stomach tube, 
six metabolites were isolated and purified via thin-layer chromatography. 
The main metabolite was identified as one of the two enantiomorphic isomers 
of 6,7-trans dihydroxy-dihydro-aldrin (aldrin diol), with a specific 
rotation of -13.7. Identification was confirmed by gas chromatography. 
After intravenous administration of this compound in rats, a more hydrophylic 
compound was found which corresponded to one of the other five compounds after 
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