
Dichlone (Phygon) [2,3-Dichloro-1,4~naphthoquinone ] 
Experiments indicated that the key oxidations of glucose, acetate, 
pyruvate, and a-ketoglutarate were inhibited by dichlone. Since eoenzyme 
A is the only factor common to all these reactions, the data strongly in- 
dicated that coenzyme A was inactivated. Other studies have also shown 
that dichlone inhibits enzymes with free sulfhydryl groups. Whether 
subsequent degradation of the CoA complex occurs is not now known (962, 
1121, 1122). 
Under ultraviolet light, dichlone reacted with pyrid ne nucleotides 
and underwent reduction (1547). 

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