Dichloran (Botran, Ditranil, Allisan, DCNA) [2,6-Dichloro-4-nitroaniline] 
After oral administration of er ei aueled dichloran to male rats, 
Dichloran was rapidly absorbed, metabolized, and excreted with 89% of the 
label in the urine. Urinary excretion was first order, k=0.199/hr. and 
Ti/ = 3.5 hours. Twenty-four hour urine pools contained only free and 
cantueaced 2,6-dichloro-4-hydroxyaniline (DCHA); 1 dichloran: 1 dichloran 
glucuronide: 6 dichloran sulfate. Hydrolysis of the urine showed two 
compounds in addition to traces of starting material. 4-amino-3,5- 
dichlorophenol accounted for 70% of the urinary radioactivity; 4-amino-2,6- 
dichloroaniline for about 2.4%. Small amounts of an aryldiamine was indicated 
(392, 393). 
In vitro studies showed that mouse liver microsomes converted dichloran 
to the aminophenol and the phenylenediamine. TLC showed that this con- 
version was small. About 91% of the Botran was recovered unchanged (393, 
934). 
Excretion of urinary radioactivity in human subjects could be described 
by two simultaneous pseudo lst-order process with mean rate constants:of 
0.0749 and 0.0260/hour, which are equivalent to excretion half-times of 9.26 
and 27.4 hours, respectively (392). 
Dichloran was strongly fixed in clay soils and was not completely 
extracted from treated soils. It was slightly water soluble and leached 
slowly (571). 
Dichloro-4-nitroaniline (DCNA) was readily taken up and translocated 
by both tomato and lettuce and was rapidly degraded to unidentified polar 
metabolites. Labeled carbon from DCNA-C!* appeared in the carbohydrate 
plant constituents (861). 
aR 
NH NH, QH | 
Cl- Cl Cl- Cl Cl- Cl Cl -Cl 
areca Dy re AP ricco AE . 
Dichl DCHA Glucuronide 
ake poo (4-Amino-3,5- and 
Dichlorophenol) Sulfate 
154 

