Dimethoate (Rogor) [0,0-Dimethyl S-(N-methylacetamide) phosphorodithioate } 
Rats degraded dimethoate to the oxygen analog, the carboxy derivative, 
desmethyl dimethoate, the 0,0-dimethyl-phosphoric, phosphorothioic, and 
phosphorodithioic acids. Several other compounds were unidentified. When 
the carboxy derivative was administered, 0,0-dimethyl phosphorodithioic, 
0,0-dimethyl phosphorothioic, and 0,0-dimethyl phosphoric acids were found. 
Highest levels of radioactivity persisted in the liver, skin, and bone. 
Dimethoate residues were present as long as 672 hours after administration 
(167, 339, 840, 1168, 1266, 1438). In studies with rat liver homogenates, 
desmethyl dime ioate, the S-acetic acid analog, dimethyl phosphorothioate 
and dimethyl - .osphorodithioate were identified (1039). Mice, exposed to 
dimethoate, excreted mono- and di-methyl phosphate and di-phosphate and 
orthophosphete (1079). 
Dimethoate was applied dermally to a lactating cow. Thin-layer 
chromate :apr indicated the presence, in addition to dimethoate, of 
dimetho: .2, '.1methoate acid and desmethyl dimethoate in the blood; and 
of time..oxon, dimethylthio (or dithio) phosphate and possibly desmethyl 
dimethoate in the milk. Several additional materials were not observed 
(359). 
From urine samples from a steer treated with labeled dimethoate, the 
following metabolites were isolated and identified: 0,0-dimethyl S-carboxy- 
methyl phosphorodithioate, O-methyl S-(N-methylcarbamoylmethyl) phosphoro- 
thioic acid, 0,0-dimethyl phosphoric acid, 0,0-dimethyl phosphorothioic 
acid, and 0,0-dimethyl phosphorodithioic acid. Of 34 tissues tested for 
residue levels, liver and kidney contained the greatest amount of total 
dimethoate equivalents and of actual dimethoate (339, 758). Similar 
results were obtained with sheep (265). Other mammalian studies have in- 
dicated that the predominant path was dependent on species, sex and con- 
centration of the dimethoate. 
In the pheasant, the toxic thiolate analog tends to accumulate and 
its conversion to one of the other metabolites is much slower than in 
mammals. This probably explains the greater susceptibility of the 
pheasant (1266). 
When P34-labeled dimethoate was applied to bollworm larvae (Heliothis 
zea) and adult boll weevils (Anthonomus grandis), metabolic products were 
similar to those reported for mammals (203). From internal extracts of 
topically treated boll weevils, seven metabolites were isolated and identi- 
fied. Among these were dithioate, and the thiocarboxy and oxygen analogs 
of dimethoate, and what was believed to be the oxycarboxy analog. Bollworms 
were treated by injection of labeled dimethoate. The highly toxic oxygen 
analog was highest in concentration. Later, considerable amounts of dithioate 
were found. The metabolite of major imporance which was found was dimethyl 
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