
Rover ercrec Reba 


Dimethyl Sulfoxide (DMSO) 
The metabolic pathway for metabolism of DMSO was the same for all 
modes of exposure observed--oral, dermal or intraperitoneal. After 
exposure of rats, rabbits, guinea pigs and man to DMSO, the corresponding 
sulfone (DMSQ,) was observed in serum and/or urine (535, 697, 698, 701, 
1505, 1661). Mixed melting point, elemental analysis and infrared were 
used to confirm the identity of the sulfone (697). In the exhaled breath 
of all animals tested, dimethyl sulfide was detected (821, 1505). The 
presence of this material in the breath of cats also was confirmed by means 
of gas chromatography and mass spectrography (372). 
0 0 
I CH t CH 
ra ae Se cal win Cie 
CH, S CH, 3 i 3 
0 
DMSO Dimethyl sulfone 
(CH.),-S 
Dimethylsulfide 
167 
