Dimetilan [2-Dimethylcarbamoy1-—3-methyl-5-pyrazolyl dimethylcarbamate ] 
Labeled dimetilan was administered orally to rats. Within 4 hours after 
treatment, the urine contained 10% of the administered radioactivity and an 
additional 3% within the next 18 hours. Two metabolites were recovered but 
not identified (1545). Some production of co, was observed (836). 
Other studies have shown a microsomal system, requiring TPNH and 
oxygen, that acts on N,N-dialkyl carbamates. Dealkylation occurs with 
formation of formaldehyde from N,N-dimethylcarbamates but not from N-methyl- 
carbamates. Dimetilan was degraded by this system (676, 677); and 2-methyl- 
carbamoy1l-3-methyl-5-pyrazolyl dimethyl carbamate plus two unidentified 
compounds were observed (1111, 1112). 
Dimetilan had a half-life in houseflies (Musca domestica L.), the 
American cockroach (Periplaneta americana L.), and the German cockroach 
(Blatella germanica L.) of less than 0.5 hours. Hydrolysis of the carbamate 
ester group accounted for some metabolism, since 13% of the injected dose 
was liberated as clio, within 1 hour after injection of dimetilan. Nine 
metabolites were detected from the German cockroach; 6 from the American 
cockroach; and 4 from the housefly. Chromatography indicated that the meta- 
bolite formed first and the major product was probably 2-dimethylcarbamoy1-3- 
methyl-5-pyrazolyl N-hydroxymethyl N-methylcarbamate. This could serve as a 
precursor for 2-(N-hydroxymethyl N-methyl) carbamoyl-3-methy1l-5-pyrazolyl 
N-hydroxymethyl N-methylcarbamate, thought to be the structure of another 
of the metabolites found in both cockroaches but not in the housefly. A 
third metabolite found in all 3 insects co-chromatographed with 2-N-methyl- 
carbamoyl-3-methyl-5-pyrazolyl dimethylcarbamate and exhibited the same 
biological activity (1544, 1545). 
Exposure of dimetilan to ultraviolet radiation gave rise to three de- 
gradation products, one of which was identified as the monomethyl compound 
3-methy1-5-hydroxy-pyrazol-5-dimethylcarbamate (391). 
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