Dinitro Compounds (Aromatic) 
DNBP [2-sec-Butyl1-4,6-dinitrophenol ] 
DNPP (2,4-Dinitro-6-isopropylphenol ] 
Binapacryl [2-sec-Butyl-4,6-dinitrophenyl 3,3-dimethylacrylate] 
Paper electrophoresis of serum of rats poisoned by consumption, in- 
halation, or skin exposure to the herbicides dinitroisopropyl-(DNPP) and 
dinitrobutylphenol (DNBP) showed DNPP- and DNBP-albumin complexes. Liver, 
kidney, spleen, and blood contained metabolites. Although not identified, 
chemical reactions indicated that both herbicides were enzymatically re- 
duced in the liver to primary amines (647, 648). 
The urine of rabbits and rats fed DNBP and its esters were collected 
and examined for metabolites, Side chain oxidation and nitro reduction 
were observed. After feeding DNBP to rabbits, five metabolites were 
observed with paper chromatography. Similar results were obtained with 
DNBP-acetate and DNBP-1,l-dimethylacrylate. In addition to unchanged DNBP, 
2-amino-4-nitro-6-sec-butylphenol and its glucuronide, §-methyl-8{2-hydroxy- 
3,5-dinitrophenyl) propionic acid and an unidentified compound (416). 
Binapacryl was absorbed poorly, if at all, through the skin of mice 
and rabbits. When administered orally to guinea pigs, this compound gives 
rise to DNBP in the blood. Death of experimental animals occurred only 
when the level of DNBP in the blood reached a critical level, indicating 
that toxic effects of binapacryl were caused by the DNBP produced in the 
tissues (144). 
DNBP was degraded by Corynebacterium simplex but only negligible amounts 
of nitrite were observed (575). 
Between 250 and 290°C, DNBP lost the OH group (1761). 
170 

