


Dioxathion (Delnav) 
[2 ,3-p-Dioxane S,S-bis(0,0-diethyl phosphorodithioate) ] 
When applied dermally to cattle, dioxathion was absorbed into the 
blood rapidly and the peak level of radioactivity was reached in 3 hours; 
whereas, in orally treated animals, it occurred in 12 hours. Blood radio-~ 
activity persisted at least one week after application. The radioactivity 
pattern of the urine followed that of the blood (264). Chromatography 
autoradiography showed that diethyl phosphoric, diethyl phosphorothioic, 
and diethyl phosphorodithioic acids were the major products of hydrolysis. 
Cis and trans dioxathion, dioxane derivative, and three unknown compounds 
were also found. A highly polar compound present at the origin point in 
the chromatography of the urine was presumed to be phosphoric acid (35). 
Analyses showed that dioxathion was present in the omental fat. 
Dioxathion was hydrolyzed slowly on the plant surface but hydrolyzed 
rapidly when absorbed into the plant. Exposure to sunlight after appli- 
cation also caused formation of more polar derivatives and more potent 
cholinesterase compounds (238). 
8 
S-P-(0C5H5) 9 S 
i 
HS-P-(0C,H5) 2 
Se are Diethyl Phosphoro- 
dithioic acid 
Dioxathion | 
0 
0 
S-B-(0C2H5) 5 ! =} 
——p HO-P-(0C,H,)) ~¢—— HO-P-(0C,Hs) 9 
Se ea ey Be) Diethyl Phosphoric Diethyl Phosphoro- 
0 0 Acid thioic Acid 
HPO, 
174 
