Diphenamid [N,N-Dimethy1-2,2-diphenylacetamide } 
Labeled diphenamid was administered to male rats (Purdue-Wistar 
strain) orally, intraperitoneally, and subcutaneously. Half-lives were 
found to be 245, 235, and 210 minutes, respectively. Demethylation of 
diphenamid was found to be extensive; nordiphenamid was demethylated to 
a lesser extent. Analysis of urine showed the presence of nordiphenamid, 
diphenylacetamide, nordiphenamid N-glucuronide, N-methyl-N-hydroxymethyl 
diphenylacetamide O-glucuronide, p-hydroxydiphenamid, and p-hydroxy- 
nordiphenamid. The latter two were excreted as glucuronides and/or 
sulfates (961). 
Strawberry plants were treated with labeled diphenamid. Extracts 
were examined by two T.L.C. systems and gas chromatography. Radioauto- 
graphs of T.L.C. plates detected unchanged diphenamid and N-methyl-2-2- 
diphenylacetamide, diphenylacetamide, and diphenylacetic acid, p-hydroxy- 
diphenylacetic acid, o-hydroxy-diphenylacetic acid. Several additional 
compounds were implied but their identity were not established (555). 
Studies were conducted with tomato plants. Diphenamid (59%); 
desmethyl diphenamid (36%); diphenylacetamide (5%); and some diphenyl- 
acetic acid were observed (862). Under sterile conditions, neither 
tomato plants nor barnyard grass metabolizes diphenamid within 16 days 
of application (length of experiment). Exposure of these treated plants 
to the soil fungi Trichoderma viride and Aspergillus candidus gave rise 
to both N-methyl-2,2-diphenylacetamide and 2,2-diphenylacetamide (783, 
784). In soils, diphenamide gave rise to MDA, DA, the acid analog and 
some unknown compounds (554). 
Aqueous solutions of diphenamid were irradiated with ultra-violet 
light at 2537A. Analysis of the resultant mixture showed the presence 
of benzoic acid, benzophenone, benzyhydrol, N-methyl-2,2-diphenylacetamide, 
and a compound believed to be N-formyl-2,2-diphenylacetamide. A polymeric 
material and some other unidentified compounds were also present (1236). 
