Ethylene bis (dithiocarbamate, 
Nabam = Disodium salt 
Maneb = Manganese salt 
Zineb = Zinc salt 
The effectiveness of ethylene disdithiocarbamates was thought to be 
dependent on the formation of ethylene thiuram monosulfide and its ulti- 
mate conversion to isothiocyanate which may react with sulfhydryls. The 
pH conditions, type and amount of inorganic salt present, and the order 
of mixing, all affected these conversions. Some free ethylene bisdithio-~ 
carbamic acid was always present in solutions of its salts because of 
hydrolysis. Salts of the acid degraded to ethylene thiuram monsulfide 
and polymeric ethylene thiuram monosulfides (88, 310, 805, 1034, 1129, 
1302, 1305, 1310, 1442). 
Except for Cut+ salts, dithiocarbamates inhibited polyphenol oxidase 
by complexing the enzyme or increasing metal dissociation. Inductance 
effects of the amine "N" substituents and the tautomerism of the "S" atom 
to sulfhydryl played an important role in this aspect. Phosphorylation 
of glucose and mannose was interrupted through inhibition of 6-phospho- 
gluconate and glucose-6-phosphate dehydrogenase (384, 739, 906, 907, 1118, 
1197. SOG. = LOM: 
188 
