Ethylene bromohydrin [1-Bromo-2-hydroxyethane ] 
Ethylene dibromide (EDB) [1,2-Dibromoethane ] 
Ethylene dichloride [1,2-Dichloroethane ] 
1,2-Dichloroethane reacted with the free sulfhydryl group of cysteine 
to form the thioether S,S'-ethylenebiscysteine, No chlorine was found in 
the reaction product. From fish solids treated with 1,2-dichloroethane, a 
sulfur-containing compound was obtained that exhibited the same R. as the 
synthetic thioether S,S'-ethylenebiscysteine; however, isolation “and 
characterization was not carried out (1619). 
H,N 
2 
‘bu-cu, si + C1-CH,-CH,~Cl 
iat 
} 
HON NH, 
Nwui-ci,-S-CH,-Cll,-8-CH,-CH 
HO-C N\ 
\ = 
: OH 
The metabolism of ethylene dibromide was studied after administration 
to rats by stomach tube. Three metabolites were isolated from urine and 
identified: (1) N-acetyl-S-(f-hydroxyethyl) cysteine; (2) S-—(f-hydroxy- 
ethyl) cysteine; and (3) S-(f-hydroxyethyl) mercapturic acid. The same 
metabolites were detected in urine after administration of ethylene dichloride 
or ethylene bromohydrin to rats (1065). 
A thorough discussion of the sorption of ethylene dibromide on various 
soils and the thermodynamics of adsorption by Ca-montmorillonite, Ca- 
kaolinite, and other soils has been presented (221, 222, 223, 750, 751, 1619, 
1620). Sorption coefficients have been tabulated for soils of different 
organic, moisture and clay content. Temperature coefficients of sorption 
could be calculated from 
K =k) 5 [1-0.0485(t-15]. 
204 
