Frescon (Wl 8008, Trityl Morpholine) [N-Triphenylmethyl morpholine] 
Crops were grown under greenhouse conditions in soil treated with 
labeled tritylmorpholine. The major metabolite found in rice plants 
was triphenylmethanol. Some unchanged material and small amounts of the 
o-, m- and p-hydroxytriphenylcarbinols, free and conjugated, were also 
observed (113, 114, 115). 
In water, N-tritylmorpholine hydrolyzed to triphenylmethanol. The 
rate was dependent upon pH. At room temperature (22°C) and at initial 
concentrations of about 0.05 ppm, the pH and half-life are related over 
the range pH 6-9 (112) 
log, (t 1/2) = (pH-6) 
Rats and dogs were given labeled Frescon as single oral doses. No 
chao was expired and less than 3% of C!* remained in carcass and skin 
after 96 hours. Frescon rapidly hydrolyzed to triphenylcarbinol and 
morpholine in the stomach. Morpholine was rapidly absorped and excreted 
largely unchanged though some was degraded. Triphenylcarbinol was 
absorbed slowly and oxidized to p-hydroxyphenyldiphenylcarbinol; and 
triphenylcarbinol and its p-hydroxy analog were found in urine, bile 
and feces, both free and conjugated with glucuronic acid. Traces of 
ortho and meta hydroxyphenyldiphenylcarbinol were detected both free 
and conjugated. There appeared to be three glucuronide fractions, 
possibly diglucuronides of hydroxytriphenylcarbinols, carbinol-group 
derived glucuronides and phenolic-group derived glucuronides (1734). 
214 
