Furadan (NIA - 10242) [2,2-Dimethyl 2,3-dihydrobenzofurany1-7-N 
methylcarbamate ] 
Male Swiss mice were administered orally a solution of labeled furadan 
in propylene glycol. Urine was collected and chromatographed. In addition 
to Cra 3-hydroxy furadan (IV) (the major component) and 3-keto furadan 
(VIII) were identified. After acid hydrolysis of the aqueous portion of 
ether extracted urine, the 3-keto-furadan phenol (IX), furadan phenol (VI), 
3-hydroxy furadan (IV) and two unidentified compounds were found (990). 
In other studies with laboratory rats, after oral administration of 
labeled furadan in Tween 20, six metabolites were identified. Analyses 
also indicated the presence of conjugates and three unidentified compounds. 
Found and identified were: 3-hydroxy-N-hydroxymethyl furadan (III) and its 
conjugate (XI); N-hydroxymethyl furadan (II); 3-hydroxy furadan (IV) and 
its conjugate (V); 3-keto furadan (VIII); 3-hydroxy furadan phenol as a 
conjugate (XIII); 3-keto furadan phenol (IX) and its conjugate (XIV); and 
furadan phenol (VI) and its conjugate (XII) (375). 
Incubation of furadan with rat liver homogenates gave rise to compounds 
II, III, IV, VI, VII, IX, one unidentified compound and some water soluble 
materials (375). 
When exposed to furadan, the dairy cow excreted 12, 1.0 and 2.6% of 
the carbony1-c!" label in urine, feces, and milk, respectively. Ring-c!" 
was excreted to the extent of 83, 2.9 and 0.5%, respectively. In the urine, 
seven metabolites were identified: 3-hydroxy furadan (IV) (52); 2,3- 
dihydro-2 ,2-dimethyl-7-benzofuranyl sulfate (XX) (38%) and glucuronide (XII) 
(7%) 3; 2,3-dihydro-2 ,2-dimethy1-3-oxo-7-benzofuranyl sulfate (XXII) (9%) and 
glucuronide (XIV) (14); 2,3-dihydro-2,2-dimethy1-3-hydroxy-7-benzofurany1l 
sulfate (XXI) (3%) and glucuronide (XIII) (12.5%). 
In other studies, after administration of furadan to a cow, about 
0.2% of the dose was eliminated in milk, 0.7% in the feces and 94% in 
the urine. Analysis of the milk revealed the presence of 3-hydroxyfuradan, 
3-hydroxy-N-hydroxymethylfuradan, 3-keto furadan, 3-hydroxyfuradan phenol 
and an unidentified compound. These were present in both the free and 
conjugated forms. In the urine, the following metabolites were found: 
3-hydroxyfuradan, 3-hydroxy-N-hydroxymethylfuradan, 3-hydroxyfuradan phenol, 
3-keto-furadan phenol and furadan phenol. In the feces, the patter of 
metabolites was similar to that observed in the urine except that 3-keto 
furadan was found but 3-keto furadan phenol was not present (1694). 
In alfalfa, labeled furadan was metabolized to free and acid labile 
conjugates of 3-hydroxy furadan (IV) (45%); 2,3-dihydro-7-hydroxy-2,2- 
dimethylbenzofuran (VI) (5%); 2,3-dihydro-7-hydroxy-2 ,2-dimethy1-3-oxo 
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