benzofuran (IX) (21%); and 2,3-dihydro-3, 7-dihydroxy-2,2-dimethylbenzo 
furan (VII) (152). In the cow, 3-hydroxy furadan (IV) was metabolized 
and excreted as the glucuronide (V) (10%). The carbonyl-c!* label from 
alfalfa conjugates of 3-hydroxy furadan was excreted in urine (38%), feces 
(18%) and in milk (2.6%) (1641). 
Following topical application of furadan to houseflies, there was 
evidence of formation of only trace amounts of N-CH»,0H derivatives (990). 
The major metabolite observed was 3-hydroxyfuradan, free and conjugated. 
3-keto furadan, 3-hydroxy-N-hydroxymethyl furadan and its conjugate, and 
N-hydroxy furadan and its conjugate were also identified (375). In other 
studies with houseflies (Musca domestica) , c!*0. was obtained from N-c!4H 
as well as from C =0 labeled furadan (1001). 
In vitro oxidation by mixed function oxidases of housefly microsomes 
converted furadan into twelve metabolites. Of these, nine were characterized: 
a 3-keto-dihydroxyfuradan (XVI); 3-keto-6-hydroxyfuradan (X); 3-hydroxy 
furadan (VI); 3-keto furadan (VIII); 2-hydroxymethyl~3-keto furadan (XVIII); 
3-hydroxy-N-hydroxymethyl furadan (III); 3-keto furadan phenol (1X); furadan 
phenol (VI); and 2-hydroxymethyl-3-keto furadan phenol (XIX) (990). 
After ingestion of furadan by the salt marsh caterpillar, Estigmene 
acrea, compounds IV, V, VI, VII, VIII, IX, XIII and XIV were identified (990). 
Radiolabeled furadan carbonyl-c!” and ring-c!", was injected into the 
stem of young bean plants (Garden snapbeans, Contender variety). Thin 
layer chromatography was used to identify the metabolites. Found free 
and as a water soluble conjugate were: 3-hydroxy-N-hydroxymethyl furadan 
(III); 3-keto furadan (VIII); 3-hydroxy furadan phenol (VII). Found con- 
jugated only were 3-hydroxyfuradan (IV) and 3-keto furadan phenol (IX). 
Furadan phenol (VI) was observed only as the free compound. Separation 
of the conjugates into two bands by TLC indicated that two naturally 
occurring compounds were conjugating the metabolites (1563). 
Exposure of intact cotton plants to furadan gave rise to 3-hydroxy- 
furadan which was oxidized readily to the keto analog. This was followed 
by hydrolysis and conjugation of the resulting phenols. A compound be- 
lieved to be the conjugate of 3-keto-6-hydroxy-furadan was also observed 
(990). 
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