Imidan [0,0-Dimethyl S-phthalimidomethyl phosphorodithioate ] 
After dermal application, imidan was moderately absorbed by the skin 
of a steer. Approximately 9.6% of the applied dose was recovered in excreta 
within 7 days and less than 2% from blood. The principal route of elimi- 
nation was via the urine in which almost 8% of the applied dose was recovered 
within 7 days. Paper chromatography and electrophoresis indicated that the 
primary metabolic products were phthalamic and phthalic acids. The presence 
of benzoic acid, a decarboxylation product of phthalic acid, was indicated 
also but not conclusively proven (263). 
In rats, 79% of the administered dose was eliminated via the urine and 
19% via the feces. About 2.6% remained in tissues. Hydrolysis predominated 
as in the steer and cotton plant (465). After oral administration of labeled 
imidan to rats, the aqueous fraction remaining after extraction of urine with 
benzene contained 98% of the labeled imidan metabolites excreted in urine. 
Using paper chromatography, the following metabolites were found: phthalic 
acid and a derivative, phthalamic acid, and about eight other unidentified 
compounds. In the benzene fraction, imidoxon, N-hydroxymethylphthalimide and 
phthalimide were observed. After acid hydrolysis of metabolites in the 
benzene and aqueous fractions of urine, chromatography by paper and TLC 
showed the presence of phthalic acid and 3- and 4-hydroxyphthalic acid 
(1690). 
In the rat feces, imidoxon and unchanged imidan were found. Indications 
of phthamic acid was also observed. Hydrolysis of aqueous extracts converted 
all metabolites to phthalamic acid (1690). 
Incubation of imidan with a rat liver microsome system, in the presence 
of NADPH, gave rise to four metabolites not identified (1690). 
After application of imidan to German cockroaches, imidoxon and 
phthalamic acid are indicated by paper chromatography. Hydrolysis of 
material not soluble in acetone converted the labeled material to phthalic 
acid (1690). 
Phthalamic and phthalic acids were found as metabolic or hydrolysis 
end products also in water, the German cockroach [Blatella germanica (L.) ], 
and the rat (980). When incubated with fly homogenate and NADPH,, imidan 
gave rise to its oxygen analog and other unidentified compounds (1427). 
Hydrolysis of imidan occurred in soils; and tests indicated that this 
was not dependent on moisture alone but was due in some degree to microbial 
action. In dry sandy loam soil, the time for 50% degradation was 19 days, 
compared to 3 days in moist soil (979). 
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