Isolan [1-Lsopropy1-3-methy1-5-pyrazolyl dimethylcarbamate ] 
Pyrolan [1-Pheny1l-3-methyl-5-pyrazolyl dimethylcarbamate] 
After exposure of rats to labeled isolan, eo, was found (836). 
When incubated with a rat liver microsome-NADPH, system, isolan was degraded 
to l-isopropyl-3-methylpyrazolone and a number of unidentified compounds 
CHIN Gis, Adee CML 2 Se, 
It has been shown that microsomal enzymes, requiring TPNH and oxygen, 
act on N,N-dialkylcarbamates. Dealkylation occurs with formation of 
formaldehyde from N,N-dimethylcarbamates. In such a system isolan was 
degraded and formaldehyde was released at acid, but not neutral, pH. 
Pyrolan reacted similarly (677). 
Exposure of isolan to ultraviolet radiation showed formation of l- 
isopropyl-3-methyl-pyrazolone and an unidentified compound. Similar treat- 
ment of pyrolan gave rise to l-phenyl-3-methylpyrazolone. Three unidenti- 
fied compounds were also observed after prolonged irradiation (391). 
After about 75 - 100 days, isolan was completely lost from soils 
(5:79). 
CH3 


Isolan 
Pyrolan 
228 
