Matacil [4-Dimethylamino-3-cresyl N-methylcarbamate ] 
When labeled Matacil was administered to rats, ero, was observed. 
(836). After incubation with a rat liver microsome-reduced nicotinamide- 
adenine dinucleotide phosphate system, Matacil was degraded to N-hydroxy- 
methyl matacil, 4-amino-3-cresyl N-methylcarbamate, 4-methylamino-3-cresyl 
N-methylcarbamate (1110, 1111, 1112). 
After exposure of flies to labeled Matacil, GE! 705 arose through N- 
dealkylation and hydrolysis to the respective phenol and methylcarbamic 
acid. The latter decomposed to CO, via formate (1001). Incubation of 
matacil with fly homogenates and NADPH, gave rise to 4-formamido-, 4-methyl- 
formamido-, 4-amino-, and 4-methylamino-3- cresyl methylcarbamates (1427). 
After treatment of growing bean leaves with labeled Matacil, at least 
eight compounds were detected. Of these, four were identified as 4-form- 
amido-, 4-methylformamido-, 4-amino-, and 4-methylamino-3-cresyl methyl- 
carbamates ( 2, 3, 845). 
Exposure of Matacil to ultraviolet light (2537 A) produced at least 
eleven degradation products. Of these, the four compounds identified were 
identical with those found on bean plants (1, 2, 3). 


ain O. 
H CH, 
Ny 
cif; H 
Matacil 4-Methy1formamido-3- 4-Me thy lamino-3-cresy1 
cresyl methylcarbamate me thy lcarbamate 
O=(-NH-CH,0H O=C-NH-CH3 
O OH 
: C 
Ol; CH H, 
CH3 CH, CH, CH, 
N-Hy droxyme thyl 4-(N-Dimethyl- 4-Amino-3-cresyl 4—~Formamido-3- 
Matacil amino) m-cresol methylearbamate cresyl methylcarbamate 
237 
