Menazon [0,0-Dimethyl S-(4,6—diamino-s- triazin-2-ylmethyl) phosphorodithioate] 
After an oral dose of cl4_1abeled Menazon to rats, 804 of the label 
appeared in the urine within 24 hours. The major metabolites found in the 
urine were identified as compounds II, VII and VIII of the metabolic 
pathway shown. Metabolite IV and three unidentified compounds were also 
observed. It was felt that Menazon or its oxon analog was hydrolyzed and 
then methylated to give the methylthiotriazine (VI). This was then oxidized 
to the sulfoxide (VII) (519). 
ae 
o~ 
No IN ‘ 
HN NAH CH ,-S-B- (OCH) 4 
ee a" Fa Thies 
a~ Seo See 7 ae A 
Hanky Dect 0% BrA 3 3s 
HoN N CH)-S-P-(OCH,), | HoN N° CHSH 
III II Vv ce 
NH, NH, NH, 
a ao~ ~ 
N N N 4 
ww, Panis it iA, Aciy-s-f-oc, 
IV VIII 

Labile Po 
<~<—— ji. fs 
Derivative nw Acay-f-cn, 
238 
