Piperonyl Butoxide 
Sulfoxide 
Exposure of Madeira roaches to c!4-labeled piperonyl butoxide gave 
rise to several water soluble metabolites which were unidentified. Distri- 
bution of radioactivity showed that the brain and thoracic ganglia, fore- 
and hind-~gut, and Malpighian tubules of the kidney contained the greatest 
amounts of radioactivity per unit weight (1275). 
Within 48 hours after oral administration of methylene-c!4 labeled 
dioxyphenyl compounds, mice excreted 61 to 764 of the label as CA7 044 The 
amount excreted within 48 hours via urine varied with compounds. Metabo- 
lism of the methylenedioxyphenyl compounds in houseflies was apparently 
slower with less complete scission of methylenedioxy grouping than in mice. 
Piperonyl butoxide and sulfoxide gave rise to unidentified water soluble 
products. Mice degraded piperonyl butoxide to 8 compounds. The methylene- 
dioxy moiety was cleaved and formate was produced (244, 755). 
C 
ah " FLY H ( a 
x. een \ 
0 
Mice 



Mouse Liver 
Microsomes + NADPH, 

HO-CH 9 HO yD 
1 
| Ro Ry 
Piperonal butoxide -CH5-CH,-CH3 -CHy-(OCoH ) -0C Ho 
Sulfoxide -H ¥ “Cy GH C7 
H3 
251 
