
Nicotine (I) 
0 
tl 
“NYY CH-CH»-CH»-C-OH 
| we NH-CH3 

5-(3'-pyridyl)-N-methyl- y-methy lamino-y-(3-pyridyl) 
pyrrolidine-2-o1 butyric acid (II) 
(VIII) oe yt 
Poe Cotinine (III) A 
| O 

nH 
| NX es ear mc 
CH3 
A, 
N 
Desmethylcotinine B-oxo-y-(3-pyridyl)-N-methyl- 
(V) butyramide (IV) 
of 
aS =0 " 
| N 'ycH-C-0H 
A Cig 
N 7 
N 
2-Pyridylacetic acid 
(VII) 
Hydroxycotinine (VI) 
260 
