Pyromat [4-methyl-2-propy1-6-oxypyrimidy1-N,N-dimethylcarbamate ] 
After extraction of urine, paper chromatography and chemical re- 
actions were used to determine those metabolites that were present. 
Metabolite I was identified as 4-methyl-2-propyl-6-hydroxypyrimidine 
(m.p. 144°C) after preparation from pyromat by hydrolysis. Studies with 
mice, rats, guinea pigs, and rabbits indicated that metabolite III arose 
from the loss of the carbamate group from metabolite II. Metabolite III 
was believed to be 4-methyl-2-propy1-5,6-dihydroxypyrimidine. After 
oral feeding of II to rats, only III and unchanged II were detected, 
thereby demonstrating that two paths of degradation existed (1189). 

Pyromat ui 

Il EEL 
282 
