SD 8447 [2-Chloro-1-(2,4,5-trichlorophenyl)vinyl dimethyl phosphate] 
p32_labeled SD 8447 in soybean oil was administered via stomach tube 
to male and female Wistar rats. There was rapid metabolism to hydrolysis 
products of low toxicity to mammals. p32 in the urine was present as di- 
methyl hydrogen phosphate, methyl dihydrogen phosphate and desmethyl 
SD 8447 (1493). 
Single doses were almost completely eliminated by rats in four days 
with 78% of the label appearing in the urine, 16.5% in feces, and 0.5% in 
expired gases. In dogs, after oral administration, 92% of the label 
appeared in the urine during four days. Metabolic products identified in 
the urine of rats and dogs were, respectively (11): 2,4,5-trichlorophenyl- 
ethanediol glucuronide (V) (8, 122); [1-(2,4,5-trichlorophenyl)ethyl 8-D- 
glucopyranosid] uronic acid (VII) (35, 0%); 2,4,5-trichloromandelic acid 
(VI) (24, 122); 2-chloro-1-(2,4,5-trichlorophenyl)vinyl methyl hydrogen 
phosphate (II) (4, 46%); 2,4,5-trichloroethanediol (IV) (2.5, 4%); and 
1-(2,4,5-trichlorophenyl)ethanol (III) (2, 0%). 
Recent studies have shown that this compound reacts with and is 
bound by proteins in the blood plasma of mammals and in homogenates of 
housefly heads (155). 
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