Temik [2-Methyl-2-(methylthio)propionaldehyde O0-(methylcarbamoy1) oxime ] 
Male rats (Carworth Farms-Elias stock) were treated orally and 
intraperitoneally with labeled Temik in ethanol and Temik sulfoxide in 
water. The excretion of S-methy1-c!* (1) and tert-butyl-c!"* (2) temik 
was completed, essentially, in four days. The N-methy1-c!* (3) was 
excreted in urine and feces up to 11 days. In collected urine, four 
metabolites were identified as: 2-methyl-2(methylsulfinyl) propionaldehyde 
oxime (III), 2-methyl-2(methylsulfinyl)propionaldehyde O-(methylcarbamoy1) 
oxime (V), 2-methyl-2{methylthio) propionaldehyde oxime (II) and 2-methyl-2- 
(methylsulfonyl) propionaldehyde oxime (IV). Three other metabolites were 
not identified (810). 
* rae Q * 
CH Becht actos nolan 
3 | | 3 
CH, H 
Cie (2) (3) 
In other studies, 80% of the dose was rapidly excreted in the urine 
and 4% via feces within 24 hours. Half of the metabolites in the urine 
were not extractable into organic solvent and remained unidentified. The 
remainder was tentatively identified as: 
2-methyl-2-methylthiopropionaldoxime (II); 
2-methyl—2-methylsulfinylpropionaldoxime (III); 
2-methyl-2-methylsulfonylpropionaldoxime (IV); 
2-methyl-2-methylsulfinylpropionitrile (VIII); 
2-methyl-2-methylsulfonylpropionitrile (IX); 
2-methy1l-2-(methylsulfinyl)propionaldehyde O-(methylcarbamoyl) oxime (V); 
and 2-methyl-2-(methylsulfonyl)propionaldehyde O-(methylcarbamoyl) oxime 
(Vilye AC 24, 2653, 
In vitro studies with subcellular fractions of rat livers were con- 
ducted. TLC was used to isolate metabolites. Compounds II, IV, V and VI 
were identified (24, 26, 1110, 1112). 
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