The major route of elimination of the Temik-S3° dose administered 
to the lactating cow was via urine. Approximately 83% of the dose was 
eliminated within 24 hours and 90% within 540 hours. Total radioactivity 
in the milk accounted for 3.02% of the dose. Only 2.85% of the Temik -53° 
was eliminated in the feces. Extracted and tentatively identified in the 
milk were eleven compounds, including temik sulfoxide (V) and sulfone (VI), 
oxime sulfoxide (III) and sulfone (IV), nitrile sulfoxide (VII) and sulfone 
(VIII), temik oxime (I, and four unidentified compounds. Metabolites 
identified in the urine were qualitatively identical but differed quantita- 
tively. Only five metabolites were identified in the feces: compounds II, 
III, V, VI and the nitrile sulfone (VIII) (1564). 
Rats were fed milk from cows treated with temik-S%5. Analyses indi- 
cated six compounds not identified in addition to temik sulfoxide (V) and 
sulfone (VI), oxime sulfoxide (III) and sulfone (IV), nitrile sulfoxide 
(VII) and sulfone (VIII) and temik oxime (II) (1564). 
Female flies (Musca domestica S and Rurp strains) were treated 
NAIDM 
topically with labeled temik. From the internal c!4 in the flies, the 
identity of temik, temik sulfone and temik sulfoxide was confirmed with TLC. 
Temik oxime arose through hydrolysis with concurrent formation of methyl- 
carbamic acid. The latter gave rise to C09. The latter also arose from 
N-dealkylation of the N-methyl group or by oxidation of the S-methyl group 
after S-dealkylation. Another compound was thought to be the hydrolysis 
product of temik oxime sulfone. Examination of feces showed that the major 
excretory product was temik sulfone. No evidence of temik sulfoxide or 
temik sulfone was observed (24, 26, 1001). 
S3°_Temik was applied topically to boll weevils (Anthonomus_ grandis 
Boheman). Externally, little hydrolysis occurred but oxidation to the 
sulfoxide was substantial. In excreta and internal extracts, twelve uniden- 
tified metabolites were observed in addition to Temik sulfoxide, the oxime 
sulfoxide, and the two corresponding sulfones (24, 26, 201). 
After injection of labeled temik into tobacco budworms (Heliothis 
virescens F.), a number of unidentified metabolites were observed in 
addition to temik sulfoxide and sulfone, the oxime sulfoxide and sulfone, 
and nitrile sulfoxide and sulfone. Trace amounts of products that co- 
chromatographed with N-demethyl temik sulfoxide and sulfone were also 
detected (201). 
297 
