Tetrachloronitrobenzene (TCNB) 
2 
3,4 ,5-TCNB 
This isomer exhibited greater absorption in rabbits than the 2,3,5,6- 
isomer. Unabsorbed 2,3,4,5-TCNB was reduced, in large measure, in the gut 
to the amine which diazotizes readily and couples. Absorbed TCNB was partly 
converted to a glucuronide (27% of dose) and to an ethereal sulfate (7% of 
dose). 2,3,4,5-aniline was isolated from urine. No mercapturic acid forma- 
tion was detected (169, 170, 171). 
NH 
05 2 
; —__ >= cn ——___ Loup led 
Cl l C Cc} 
: C1 
2,3,4,5-TCNB 2,3,4,5-Aniline 
v 

Glucuronide and sulfate 
2,3,4,6-TCNB 
After dosing rabbits with 2,3,4,6-TCNB, the corresponding aniline 
and N-acetyl-S-(2,3,4,6-tetrachlorophenyl) cysteine were found in the urine 
CLLL 
Aaa 
NO, Sie Doak Wa 
0 
Cl 1 C1 1 
> 
1 | 1 
1 l 
ae NH, 
2,3,4,6-TCNB 
Cl- 1 
1 
1 
301 
