Tinox [0,0-Dimethyl 0-(2-methylmercaptoethyl)phosphoro -thoate and 
-thiolate ] 
Studies concerning the metabolism of Tinox in tomato plants demon- 
strated the presence of both isomers as well as the oxidation metabolites 
of both isomers. Using P32_tinox and TLC, extracts exhibited the presence 
of the thiono-sulfoxide and sulfone and the thiol-sulfoxide and sulfone (358). 
TMID (Tetramethyl thiuram disulfide, Thiram) [Bis(dimethylthiocarbamoy1) 
disulfide ] 
TMTD is known to inhibit fermentation of glucose, fructose-1,6-di- 
phosphate, and glyceraldehyde-3-phosphate and to inhibit triosephosphate 
dehydrogenase (1311). MID reacted with thiols by a radical exchange 
mechanism. The final products are the corresponding disulfide of the 
parent thiol and dimethyldithiocarbamate (1123, 1274). (See also 
Dithiocarbamates and TTD.) 
In studies with ruminant animals fed corn treated with TMID, rumen 
microorganisms degraded TMTD to carbon disulfide and probably hydrogen 
sulfide and dimethylamine. Within six hours after dosage, 78% of the 
ingested TMID was recovered as CSj7. Some unchanged TMID was also observed 
in feces and urine (1221). 
CH CH CH 
< ‘jie A 
N=C=S=Ss CN oF 2GSH 9 N-C-SH 
-” 
aq uoN —<—_ a> | 
CRo Sg 5 vs ag 
| pH=5 = 
CS G-S-S-G 
2 
310 
