TOK [2,4-Dichloro-4'-nitrodiphenyl ether] 
After feeding of 5 ppm TOK in forage to cows, no residues of TOK 
were found in the milk, urine, or feces. In the presence of fresh rumen 
fluid, a metabolite was produced which had a retention time, on gas 
chromatography, identical with that of 2,4-dichloro-4'-aminodiphenyl ether 
(587). 
Toxaphene 
Very little information is available about the metabolism of toxa- 
phene. Using bioassay methods, it was found that resistant flies could 
metabolize 4.0 mcg of toxaphene from an absorbed dose of 5.4 mcg. No 
metabolites were identified. 
Toxaphene was stored unchanged in fatty tissue of treated animals. 
Infrared showed presence of all absorption bands exhibited by toxaphene. 
Comparative bioassay and total chlorine showed that total organic chloride 
in fatty tissue had about same toxicity to flies as an equivalent amount 
of toxaphene (368). 
In studies with the cotton leafworm, the presence of a dehydro- 
chlorinase and the breakdown of toxaphene was demonstrated. Three 
components were separated by paper chromatography but were not identified 
(398). 
SLI 
