Propazine-cl4 was metabolized by cane (Sorghum vulgare L.) but 
not oats (Avena) (475, 476, 477). 
In soil samples treated with propazine, accumulation of the hydroxy 
derivative indicated initial hydrolysis at the 2-position (616). 
Cl 
on 
\S a ? 
He « 7 
HAG N- - CH 
; Sou x Sot i 
H3C 
N\cH3 
Prometryne [2-Methylmercapto-4,6-bis(isopropylamino}s-triazine ] 
Rats and rabbits fed prometryne excreted 2-mercapto-—4-amino-6- 
isopropylamino-s-triazine and bis(2-amino-4-isopropylamino-s-triazinyl-6-yl) 
disulfide. The mono- and di- dealkylated prometryne analogs were also 
observed (133). See Table l. 
When cotton plants were treated with Cl4-labeled prometryne, labeled 
material accumulated in roots, stems, leaves and lysigenous glands but no 
cl4q, was detected (1496). 
Eight day old pea plants were exposed to prometryne and harvested 
eight days later. Several metabolic pathways were indicated. In one, the 
side chain of prometryn was metabolized and 2-hydroxy-4-amino-6-isopropyl- 
amino-s-triazine was identified. In the other, the methylthio group was 
oxidized to the sulfone which readily hydrolyzes to the hydroxy analog. 
Chromatography indicated the presence of the sulfoxide and hydroxy analogs 
(1165). 
Studies with E. coli showed that prometryne could replace thymine or 
uracil and was incorporated into nucleic acids (1394). Some microorganisms 
appeared to degrade prometryne by oxidation of the methylmercapto group to 
a sulfoxide or sulfone (593). It was found that some fungi also degrade 
prometryne: Penicillium cyclopium, P. frequentans, P. purpurogenunm, 
Aspergillus niger, A. repens, Ceyhalosporium acre monium and Cladosporium 
herbarum (1003). 
318 
