SEA-FISHERIES LABORATORY. 117 
a globular or oval space in the cell, containing light brown 
granules. In other cases a nucleus, exhibiting a distinct 
chromatic skein, can be made out. But the fixation of the 
tissue was not good enough to enable the nuclei to be 
studied without risk of error. 
Between the cells is a connective tissue stroma, very 
variable in degree of development. Usually it is more 
highly developed than is represented in fig. 2, since a part 
of the section as free as possible from other structures 
than the typical sarcomatous cells was selected. The 
connective tissue is of the ordinary kind, consisting of 
fibres running for the most part parallel with the spindle 
cells, but forming reticular structures in the looser parts 
of the tumour. It occasionally contains sheets, or 
flattened-out coarse fibres. Small cells, with little cell 
substance and relatively large nuclei, are present, but are 
not abundant. 
The tumour contains few blood vessels, and these are 
generally small, and are nearly always empty. Here and 
there a few corpuscles, usually rather distorted in shape, 
can be seen. The vessels sometimes contain black masses, 
evidently cells, or fragments of cells from the tumour, 
which have found their way into the lumina, probably 
because of the breakdown of the tissues in the central part 
of the growth. If, as in rare cases, the vessels contain 
many corpuscles, the latter are usually disintegrated. 
The spindle cells are usually arranged so that they lie 
side by side, presenting the appearance of bands in the 
section. Fig. 2 represents a small part of one of these 
bands, or rows rather, of spindle cells. There is relatively 
little connective tissue between the cells, but between the 
various rows of cells there is considerably more; and this 
takes the form of fibrous tissue with corpuscles (see the 
bottom of fig. 2). The rows of spindle cells run in all 
