120 TRANSACTIONS LIVERPOOL BIOLOGICAL SOCIETY 
the growth, and is drawn to the same scale as fig. 1, and 
placed alongside the latter for the purpose of comparison. 
The epidermis is here quite normal, and so also are the 
deeper layers of the dermis. But all the tissues between 
the epidermis and the lower layers of coarse connective 
tissue fibres are infiltrated by the sarcomatous growth. 
Fig. 2 is drawn to a low scale, so as to show the whole 
thickness of the skin, and the intrusive tissue is repre- 
sented by the stippled dots and the faint streaks. This 
tissue occurs down as far as the layer of coarse fibres 
overlying the muscles of the body, and it has insinuated 
itself between the dermal connective tissue layer and the 
epidermis; and between the fibres of the upper layers of 
the dermis. Approaching the edge of the tumour from 
the normal skin one finds these fibres becoming more 
loosely arranged. Then they become broken up into short 
lengths and irregular pieces, and finally disappear. Fig. 
3 represents a small part of the transition zone between 
normal and diseased tissue, as it is seen under a high- 
power lens. The darkly shaded structures are the frag- 
mented connective tissue fibres, and among these are some 
fibres and nuclei, probably belonging normally to this 
region, and the proliferated cells of the sarcoma. The 
latter cells vary in shape, some being globular, while 
others are already columnar, or spindle-shaped. All have 
normal nuclei (so far as can be ascertained, though the 
fixation leaves much to be desired in this respect); and the 
amount of melanin present in them is less than in the 
regions where the tumour tissue is more highly developed. 
Fig. 4 represents the intrusive cells in the deeper 
areolar tissue just over the body muscles, and it is some 
of these proliferated cells that are figured. The cells are, 
for the most part, globular, but some are irregular in 
shape, and others present appearances indicating recent 
