264 REPORT OF THE HARVARD AFRICAN EXPEDITION 
cells. These large cells constitute the dominating picture in the areas of necrosis. 
They are thin-walled, have a lipoid appearance with a large, usually irregularly 
shaped, lightly-staining nucleus (No. 199). The cells are round or oval and 
show some reticular markings. Some of them measure up to 80m in their 
greatest length, though they vary greatly in size. At times these cells are devoid 
of inclusions or chromatin except the nucleus. More commonly they contain 
polynuclear leucocytes or rounded masses of chromatin. In some instances 

No. 199. — Center of nodule of Case 75. Zeiss objective 2 mm., ocular 10x 
between forty and fifty small masses of chromatin, at least 3-4u in diameter, 
may be observed by actual count in single cells. These particles of chromatin 
are apparently often the nuclei of included cells, about which the protoplasm 
has disappeared. In other instances the included leucocyte with its nucleus can 
be distinguished. These large cells resemble somewhat those described as 
xanthoma cells or, according to other authorities, they follow the descriptions of 
swollen clasmatocytes or histocytes. Some of them show slight fibrils at the 
ends, suggesting that they are epithelioid cells and that they are of connective 
tissue origin. Whether they are overgrown fibroblasts or overgrown lymph 
