XXXI 
SCHISTOSOMIASIS TREATED WITH ANTIMONY SODIUM 
THIOGLYCOLLATE AND WITH ANTIMONY 
THIOGLYCOLLAMIDE 
By GeEorGE C. SHATTUCK 
AND 
PAun T.. Witiis 
ANTIMONY sodium thioglycollate and antimony thioglycollamide have been 
shown to have a toxicity considerably lower than that of tartar emetic, and have 
been used successfully in the treatment of granuloma inguinale in the United 
States by Randall! and others.? 
Believing that these drugs could be used to advantage in other diseases in 
which antimonials have proved beneficial, the Expedition took with it a supply 
of them to be tried in schistosomiasis and in African sleeping sickness. To save 
bulk and weight, and because antimony sodium thioglycollate is not stable in 
solution, the drugs were put up in powdered form in capsules, which it was 
believed would protect them sufficiently. Enough sodium citrate was mixed 
with each dose of the drug to fill the capsule. 
In order that dosage might be easily varied without waste of the drug, cap- 
sules, containing 0.1 grm. (13 gr.), and others containing 0.03 grm. (4 gr.) of the 
drug, were provided. The dose of the two drugs is the same. 
The antimonials were courteously supplied to the Expedition free of charge 
by the manufacturers, Messrs. Hynson, Wescott and Dunning, of Baltimore. 
A Cast TREATED IN LIBERIA 
In July, 1926, members of the Expedition discovered at Monrovia a case of 
vesical schistosomiasis, caused by Schistosoma haematobium. The child was said 
to be a “bush girl.”’ Probably she came from one of the interior tribes and con- 
tracted the disease there. 
Through the courtesy of Dr. Dingwall, who was in charge of the Government 
Hospital at Monrovia, the patient was admitted to that hospital, and the writers 
were accorded the privilege of treating her there with intravenous injections of 
antimony sodium thioglycollate. 
The low toxicity of this drug was shown again by an error in the preparation 
of the solution for the first injection, which was considerably stronger than had 
1 Randall, A.: Therapeutic Value of two New Synthetic Antimony Compounds in Cases of Granu- 
loma Inguinale. Journ. of Urology, 1923, IX, 491. Two New Antimony Compounds for Intravenous 
Use. Amer. Journ. Med. Sci., 1924, CLXVIII, 728. ; . 
2 Shattuck, G. C.: Treatment of Inguinal Granuloma with Thioglycollates of Antimony. Amer. 
Journ. Trop. Med., 1926, VI, 307. 
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