502 REPORT OF THE HARVARD AFRICAN EXPEDITION 
FURTHER USE OF ANTIMONY THIOGLYCOLLAMIDE 
IN BILHARZIASIS AND IN TRYPANOSOMIASIS 
By Gerorce C. SHAatTTuck 
The value of antimonials in the treatment of bilharziasis, of leishmaniasis, 
of inguinal granuloma, and to a less degree in African trypanosomiasis, has 
long been recognized. Tartar emetic has generally been used because it is 
cheap and because the newer antimonials, in general, have not given results 
which are strikingly better, but, in the treatment of inguinal granuloma in 
man, the use of antimony thioglycollamide has seemed to me to have decided 
advantages. Rowntree and Abel! demonstrated its relatively low toxicity for 
animals and it has appeared to be less toxic for man than is tartar emetic.’ 
It seems also more efficient for the treatment of inguinal granuloma than is 
tartar emetic and it has the further advantage that intramuscular injections 
in suitable dilution, and in the lower scale of dosage, may cause no painful 
reaction in some individuals, and but mild local reactions in other persons.’ 
Attention was called in an earlier paper * to the use of these drugs for bil- 
harziasis. It is now possible, through the courtesy of Dr. Clement C. Chester- 
man, Director of the Yakusu Hospital (Haut Congo Belge) of the Baptist 
Missionary Society, and of Dr. K. Waller Todd, who had charge of the hospital 
while Dr. Chesterman was on furlough, to publish some additional data not only 
on the use of the triamide of antimony in the treatment of bilharziasis but also 
in human trypanosomiasis for which it was reeommended for trial by Rowntree 
and Abel on the basis of efficiency in experimental trypanosomiasis in animals.°® 
All of the cases reported below were under the care of Dr. Todd and I am 
indebted to him for the data. 
Bilharzvasis 
Dr. Todd’s fourteen cases of intestinal bilharziasis were caused by Schis- 
tosoma haematobium, or, at any rate, by a schistosome producing an ovum 
having a terminal spine. Dr. Chesterman® has called attention to the fact 
that, at Yakusu, these ova are found in the faeces and not in the urine. 
Dr. Todd was disappointed at not being able to follow up the cases with 
an adequate number of stool examinations at intervals. It proved impossible, 
as a rule, to obtain specimens of faeces from patients after they considered them- 
selves well. Moreover, they generally failed to return after the Symptoms 
had abated, so that thorough treatment was not practicable. One relapse only 
is known to have occurred. The injections, as a rule, were given intravenously. 
1 Rowntree, L. G. and Abel, J. J.: Jour. of Pharmacol. and Exper. Therapy, 1910-11; Vol. 2s 
p. 101, and Ibid, p. 396, and Ibid, p. 501. 
2 Randall, Alexander: Jour. of Urology, 1923; Vol. 9; p. 491, and Amer Jour. Med. Sciences 
1924; Vol. 168; p. 728. ; 
8 Shattuck, G. C. et al: Amer. Jour. of Trop. Med., 1926; Vol. 6; p. 307. 
# Shattuck, G. C. and Willis, P. T.: Jour. Trop. Med. and Hyg., 1928; May 15th. 
5 Rowntree and Abel: Loc. cit. 
6 Chesterman, C. C.: Ann. Soc. Belge de Méd. Trop. Brux., 1923; Vol. 3; p. 73. 
