BILHARZIASIS AND TRYPANOSOMIASIS 903 
Table I epitomizes the records of fourteen cases. The number of doses 
taken by each patient is strikingly small. The average number of doses was 
slightly less than four. The total dosage is likewise very low, even when the 
ages of the patients are allowed for; and, lastly, the duration of treatment 
was very short in most cases. 
‘““Manson’s Tropical Diseases’ (Sth edition, p. 491) recommends for adults 
a total dosage of twenty-five to thirty grains of tartar emetic or about two grams, 
to be administered over a period of from four to six weeks. This recommendation 
follows Christopherson closely; but Table I shows that Todd’s largest total 
dose was less than half a gram and his longest period of treatment was twenty- 
four days. Todd’s shortest recorded period of treatment was four days and the 
total dose in this case was only 0.11 grams, but, even in this case, apparent cure 
resulted. 
TABLE I 
BILHARZIA CASES 
















Case No. | Age | Sex | No. of Doses | Total Dose | Dura. of Treatment Result 
I 16 M 3 0.11 Gm. 4 days Symptomatic cure. Single 
stool negative 1 month 
later. 
19% yy | F 5 0.29 “ Qe After 4th dose on 6th day of 
treatment ova still abun- 
dant. 
ELE 10 M 4 OWgr 1 a Appeared well 7 mos. later. 
IV 13 F 9 0.46 “ Dae °° Stool negative after 10 days 
of treatment. Stool nega- 
tive 1 wk. after treatment. 
V 20 M 3 C22 © DROS pi Stool negative after treat- 
ment. Appeared well 2 
mos. after treatment. 
VI 8 F 4 Onset NT ataice Appeared well 5 mos. after 
treatment. 
VII 20 F 3 O21 oie om ee Appeared well 5 mos. after 
treatment. 
VIII 8 F 4 OHIO We Petree Constipated 3 wks. after 
treatment. 
IX 11 M 2 OOS Ser 0 Benes Appeared well 5 mos. after 
treatment. 
xX 17 M 4 OSTA IN eres Robust health noted some 
time after treatment. 
XI 12 F 4 OE? IN ae smtp ete Appeared well after 2nd in- 
jection and 2 mos. after 
treatment. 
Mit 19 M 4 0.29 “ 18 days Appeared well 9 days after 
treatment. 
XIII 25 | M 3 Oeir oe ewes Diarrhoea practically ceased 
after first dose. 
XIV 20 | M 3 OED es acs Stool negative 5 days after 
treatment and patient ap- 
peared in excellent health 
2 mos. later. 



* Treatment was discontinued because of “pain in legs accentuating old arthritis but with oedema of 
feet.’ Subsequently treated with tartar emetic with good results. It seems unlikely that the triamide 
caused the pain or the oedema of the feet. 
