504 REPORT OF THE HARVARD AFRICAN EXPEDITION 
Table I shows that improvement in, or disappearance of, symptoms ap- 
peared promptly in most cases. Case 2 was exceptional in that ova were still 
abundant after eight days of treatment. 
Toxic symptoms, clearly attributable to the drug, were observed only in 
Case 5 after he had received the large initial dose of 0.10 gram. On questioning 
he then complained of headache. 
Trypanosomiasis 
Six cases of human trypanosomiasis received antimony thioglycollamide 
but, owing to the fact that they had been treated not long before with other 
drugs, it is difficult to interpret the therapeutic results. 
Three of the cases were given antimony because partial blindness had fol- 
lowed treatment with arsenicals. The fourth case had albuminuria after two 
doses of ‘‘Bayer 205.” In these four cases the dosage of the antimonial was 
small and no symptoms were caused by the drug. 
The fifth case, a male of about nineteen years of age showing ‘‘advanced 
nervous symptoms but no sleepiness,” received 0.54 gram of the drug in seven 
days. Ill effects were first noted after the last injection. Trembling started 
within one minute and lasted for several hours. Three days later shallow 
ulcers appeared on the tongue and the general condition of the patient was 
worse. Ulcers on the tongue are not a generally recognized sign of antimony 
poisoning and I do not remember having seen them previously recorded as 
such. In this case the total dosage is larger than would ordinarily be used 
during the first week of treatment for bilharzia with tartar emetic. Tolerance 
to antimony may be expected to increase gradually but caution should be exer- 
cised at first. 
In the sixth case a combined treatment was begun with thioglycollamide 
and tryparsamide which were adminstered on different days. 
Summary 
1. Antimony thioglycollamide used in the treatment of fourteen cases of 
bilharziasis of the bowel (Schistosoma haematobium) gave prompt symptoma- 
tic relief except in Case No. 2, and apparent cure resulted from its use except 
in Case No. 2 and in one other case which returned with a relapse. 
2. These results were attained although the individual doses, the total 
dosage, and the duration of treatment were strikingly low in the reported 
cases. 
3. Adequate follow-up by stool examination was not possible, but many 
of the patients appeared to be well from two to six months after treatment, 
and stool examinations made in a few of the cases after treatment were nega- 
tive. 
4. Aman of twenty who received an initial dose of 0.10 gram, on question- 
ing, said he had a headache for one day thereafter. Such an initial dose of 
tartar emetic might have been expected to cause more severe symptoms. 
