BILHARZIASIS AND TRYPANOSOMIASIS 505 
5. Antimony thioglycollamide was adminstered in six cases of trypano- 
somiasis. In one of these cases heavy dosage was employed during the first 
week and symptoms of toxic nature were produced (fifth case). 
6. Should more complete information confirm my impression that anti- 
mony thioglycollamide is more effective in equal dosage and also somewhat 
less poisonous for man than is tartar emetic, the former drug will become valu- 
able for the treatment of bilharziasis and perhaps also for certain classes of 
cases of human trypanosomiasis. 
7. A therapeutically active antimonial of low toxicity would seem to be 
indicated in trypanosomiasis as follows: 
(a) for persons unusually susceptible to arsenic 
(b) for cases in which symptoms of arsenical poisoning have appeared 
(ec) for trypanosomes which have become arsenic-fast 
(d) for use between courses of arsenicals or in conjunction with other 
medication. 
(e) for cases resistant to other forms of medication 
No antimonial has yet been found effective in the later stages of the malady 
when the nervous system has been extensively invaded by the parasites. 
8. It is believed that the manufacturer’s solution of antimony thiogly- 
collamide in ampoules is indefinitely stable but it has the disadvantage of being 
expensive. Expense can be minimized by obtaining the drug in powder form 
and by making up the solution as needed according to instructions which can 
be obtained from the manufacturer.! The pure powdered drug is believed to 
be stable. 
9. Dr. Chesterman, having tried a number of the newer antimonials with- 
out finding in them any striking advantages over tartar emetic, is skeptical 
of the value of antimony thioglycollamide. Dr. Todd, while noncommital at 
present, believes the drug worthy of further trial. I think that Dr. Todd’s 
results in bilharziasis, together with the findings of Randall and of Shattuck 
referred to above, justify the hope that antimony thioglycollamide may, ulti- 
mately, prove of greater value than other antimonials now available. 
DRINKING WATER FOR TRAVELLERS IN THE TROPICS 
By Grorce C. SHatruck 
When plans were being made for the “Harvard African Expedition,” which 
was to consist of a party of eight whites, it was realized that the most varied 
water problems would be encountered, and that it would not be easy to boil 
enough water for a party of this size. It seemed desirable, therefore, to provide 
for chlorination of larger and of smaller quantities of water as need might arise. 
1 Messrs. Hynson, Westcott & Dunning, Pharmaceutical Laboratory, Baltimore, Maryland, U.S. A. 
