1803.] 
through its refpeftive ftages. It is molt 
efficacious in produc ng the vaccina from 
a pock before theeleventh or twelfth day 5 
and is mot abundant, and isufwally taken, 
about the ninth day. But it may be ufed 
at any earl er pericd, even as early as the 
fifth day, if it can be ccliected. How- 
ever, matter fr’-ma pock later than the 
eleventh or twelith «ay is not more li- 
able to produce inflame! arms than that 
from younser pocks; and if the cow-pock 
be excited at all, ic is as diftn& as fiom 
any ea ler inatter. No differences in the 
effects of ‘he vacc nz-m‘tter inoculated ap- 
pear to depen! on the pretence, exient, or 
abience, of he reti a-eola. 
2. The matt-ris ufually taken on glafs, 
thread, or a quill, on which it fhoud be 
fufferei to become dry without, applying 
heat, and «hen fo dried, it is fe:rce vi- 
fible. ‘The air fhould be excluded, hy 
keeping the matter between two glafs 
plates, or ina bottle filed with hydrogen 
gas. 
3. As dried matter fails much more 
frequent'y to exc-te the vaccina than re- 
cent fluid matter, it will be advifeable, in 
order to infure the effect, or for obtaining 
a great quantity of matter, that, inftead 
of a fingle puncture or {cratch (which is 
futicient and preferab’e with recent mat- 
ter) there be matter inferted in two punc- 
tured or f{cratched parts ineach arm. The 
dried matter, at the time of inoculation, 
fhould be fottened by warm, but not very 
hot water. 
4. The inoculation. mutt be performed 
in the fame manner as for he {mail-pox. 
5. If the infectious matter produce the 
required effeét, in three, four, or five days, 
there will be feen a red {pot like a {mall 
gnat-bite ; in fix or feven days a fmall 
veficle will appear ; in nine days, a cir- 
cular veficle (improperly called a puf- 
tule) will be found as large as a pea, or 
from about two-tentns to four-tenths of 
an inch diameter, uiually furrounded by 
a red areola. By the eleventh day, the 
veficle begins to fcab. or grow dry, and 
turn black in the middle, and the areola 
becomes more extenfive. By the fifteenth 
day, bur often later, the pock becomesa 
mere fcab, circular, prominent, well de- 
fined, of a blackifl or mahogany colour, 
adhering firmly ; but the areola dilap. 
pears. Unlefs it be feparated by violence, 
the fcab does not fall off, in general, foon- 
er than the twentiethday. It then leaves 
a citratrix permanent for life. 
Dire&ions for pratiifing the Vaccine Inoculation. 
19 
6. If the eruption, or pimple, excited 
by inoculation, has not the characters, 
anil does not pa{s through the ftages in 
the courle above-flated (5), although 
fometimes anomalous, this cow-pock may 
render the conftitution entufceptible of the 
fmall pox, yet it cannot bedepended upon. 
In fuch cales, the inoculation thould be re- 
initituted ; for if the vacciea cannot be 
again excited, the unfufceptiLility defired 
will have been produced ; but it a further 
proof .be wanted, recourfe mutt be had to 
inoculation wits the variolous ma ter. 
7+ In many-cafes, no conftiutional af- 
fection or fever can be perceived : when it 
occurs, it is almoft always on the ninth and - 
tenth days; but provided che pock exhibit 
the diftin ‘tive characters of the cow-pock, 
even without areola, withthe ufual courfe 
of ats ftages, the fulceptibility of the 
fmall-pox will be as effectually deftroyed 
as if there had been confiderable febrile 
affection, and extenfive areola. 
8. Iferythema, like eryfipelas, extend 
over the arm, with fwelling, pain, &c. it 
jhas always fubfided in a few days of itfelf, 
only avoiding irritating applications, or 
at moft on ufing fedatives. 
g. Eruptions fometimes occur, but they 
require no particular treatment. 
10. The tmail-pox may break out at 
any period within twelve days of inocu- 
lation for_the cow-pock. If they appear 
earlier than the fixth or feventh, :he vace 
cina is cut off 10 its progrefs ; if they ap- 
pear later, the vaccina goes forward in its - 
ufua! courfe. r 
rt. Lhe medical treatment which may 
be required from unufual or fupervening. 
complaints, being analogous to that in the 
fiall-pox, muft be accordingly. 
12. Meafles, chicken-pox, hooping- 
cough, and other diforders, may intervene 
during the vaccina, without, in general, 
varying its progrefs. 
Goiden-/quare, Feb. 25, 1803. 
Note.—It has been found proper to require 
half-a guinea for arming three lancets, or for 
matter on thread or glafs : but each pradti- 
tioner may be fupplied with matter as often 
as wanted for his own “‘ufe only, by paying 
one guinea annually, the expence of poftage 
and porterage being difcharged by thofe who 
apply. 
The Inftitution does not warrant any matter 
but that which has on the package the im~ 
preffion of the feal of the Inftitution, name 
ly, a cow, with the motto, eliciores ins 
ferit. if 
i D 2 For - 
