with perfons in the fmall-pox, inoculation 
with fmall-pox matter, and re-inoculation 
with vaccine matter. But, for reafons fet 
forth in a memoir read at the guarterly 
meeting by..Dr. Pe arfon, the repetition of 
¥e-inoculation with vaccine matter is a pre- 
- ferable teft; for, it does not appear, from 
abundant evidence brought forward by the 
experience of Dr, Pearfon, that a perfon who 
has gone through the cow-pock is fufceptible 
of it a fecond time.—That fuch pra&itioners 
as are defirous of feeing proofs of the propo- 
fition laft flated, that a fecond inoculation 
for the cow-pock is an equally decifive teft 
of the queftion of the fuyfceptibilicy of a 
vaccinated perfon to take the {mall pox as 
inoculation with variolous matter, be invited 
to attend at the Inititution for that purpofe.— 
That although it is probable, from the 
amount of the deaths by the fmall-pox in 
the Bills of Mortality in two preceding years, 
viz. in 1803, of 1202; and in 1804, of 622, 
that the proportion of deaths by that difeafe 
has been diminithed by vaccine inoculation; 
yet it does not appear juftifiable to draw this 
conclufion pofitively at prefent ; becaufe, in 
former years, previoufly to the new praGtice, 
even a itill fmaller proportion occurred by 
{mall- “pox, viz. in 1795, there were only 
1040 ; in 1797, there were only 522; 
and in 1799 there were III; therefore 
that it will require at leaft five fucceflive 
years of vaccine practice to draw a juft in- 
ference—That Dr. Pearfon be requefted to 
allow the Memoir on the State of the Prac- 
tice of Vaccination, and on the conduct of 
it, to be printed, in order to quiet. the minds 
of many families difturbed by the late unfa- 
vourable reports, That the medical efta- 
blifhment continue their practice of regifter- 
ing their obfervations, as the moft likely 
Means to reduce to certainty the vaccine prac- 
tice as a prophyla&tic of the {mall pox.— 
That although the conduét of this Inftitu- 
tion, under the economical management of 
the treafurers and the truffees, has been 
fuch, that the fubfcriptions hitherto have 
been fufficient to defray the expences without 
tequefting additional ‘id from: the prefent 
fupporters ; yet, to accomplith the objetts of 
the Inftitution to their full extent, it ‘will be 
requifite that farther contributions be re- 
guefted from the Pyblic, arid that the prefent 
fubferibers, particularly, be refpectfully fo- 
licited to ufe their interef for that purpofe. -- 
The number inoculated fince the laft report, 
amounts to 2337: All perfons, with or 
without letters of recommendation, are ad- 
jitted for inoculation every Tuefday and 
Friday, at one o’clock.—It fhould be obferved, 
that, for the accommodation of provincial 
_ Tubfcribers and corr efpondents, the Poftmaf- 
ters General haye liberally granted permif- 
fion for letters to come and return poftage-free, 
provided they are addrefled to Mr. Sancho, 
decretary to the Original Vaccine Pock Infti. 
tution, Broad- -{freet, Golden-fquare, and i are 
ed 
Marrieges and Deaths in and near Lindon. 
[May 1, 
fent under cover to Francis Freeling, efq. 
Genera) Poft-office, with this indorfement—« 
‘¢On the bufinefs of the Sroad-ftreet Vac- 
cine Inftitutiom?? } : 
A fociety, to be denominated the Refuge 
of the Deftitute, has been eftablifhed, under 
the patronage of his Royal Highnefs the 
Duke of York. The pbje€t which this fo- 
ciety has in view is to provide places of re- 
fuge for perfons difcharged from prifon or the 
hulks, unfortunate and deferted females and 
others, who, from lofs of charaéter or ex- 
treme indigence, cannot procure an honeft 
maintenance though willing to work. It is 
intended, with due regard to the feparate fup- 
port and employment of the male and female 
objeéts of this inftitution, to pay the moft 
particular. attention to the improvement of 
their morals, and to afford them an opportu- 
nity of purfuing or of learning various trades 
and occupations, After they have acquired 
fuch habits of religion and induftry as may 
render them ufeful members of fociety, pro= 
per fituations will be fought for them, and 
rewards beftowed on thofe who perfevere in 
good conduét. When it is confidered that 
thoufands in the metropolis fubfift by difho- 
neft practices, while fame, it is much feared, 
perifh of want before parochial relief can be 
cheno an undertaking tending to remove 
fuch evils cannot fail to experience the moft 
general patronage and fupport. 
MARRIED, 
At St. James’s Church, Piccadilly, Mr, 
T. Goddard, bookfeller, Pall Mall, London, 
to Mifs Gienthani of Chalvey Greeny near 
Slough, Bucks. 
C. Day, efq. of Cowes, Ifle of Wight, to 
Mifs E. Marfhall, daughter of the Rev. Mr, 
Marfhall, chaplain to the Prince of Wales, 
and areas of Orfett, in Effex. 
D. Ximenes, efq. of Grafton-ftreet, fie. 
roy-fquare, to Mifs Jackfon, only daughter 
of the Rey. J. Jackfon, of MIghnErs near 
Feverfham, Kent. : 
H. Hurle, efq. of Cloak-Jane, ta Mifs 
Hartley, daughter of the late Mr. Hartley, 
of Edward-ftreet, Soho, 
'G. Lackington, efg. of Finfbury-f{quare, 
to Mifs Bullock, daughter of Captain Bullock, . 
of the royal navy. 
The Hon, C, Paget, fourth fon to the Earl 
of Uxbridge, and’ captain of his Majefty’s 
thip Endymion, to Mifs E. A. Monk, fecond 
daughter of H. Monk, efq. 
Captain Humphreys, of the royal navy, . 
to Mifs T. Morin, daughter of J. T, ; Mortitn 
efq, of Hanaver-fquare. 
The Rey. W. Upjohn, A.B. of St. Ed- 
mond Hall, Oxford, to Mifs Mary Ann 
Smith, daughter of F. Smith, , efq. of Scot’s 
Yard, 
Auguftus Hasbilton, efq: fon of vice-ad- 
miral Hamilton, to Mifs ‘Hyde, daughter of 
the late Judge Hyde. 
John Kouth, efq. of Auftin Friars, t te Mifg 
Dunbar, ‘of Camberwell Groves 
Mrs 
oe a 
