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ance of the same symptoms, together with a dull pain in the 
epigastrium, and immediately repeated the laudanum. But 
finding no relief, the dimness of sight increasing, and on mo- 
tion of the body, or turning the head, amounting almost to 
blindness, a sensation of stiffness in the voluntary muscles 
supervening, particularly the temporal and extensors of the 
head, together with considerable general prostration, the dose 
of laudanum was doubled. This produced a partial abate- 
ment of the symptoms, and after another similar interval was 
repeated, with half a gill of brandy, which soon effected en- 
tire relief. In connexion with these symptoms, it should be 
observed that I am unusually susceptible to the operation both 
of narcotics and emetics. 
The individual to whom I have alluded as also taking this 
extract, may perhaps be considered as at the other extreme 
in the range of susceptibility. He commenced at 9 o'clock 
in the evening, with two grains. In ten or fifteen minutes, 
slight uneasiness at the stomach ; at half past 9 took four 
grains more; at 10, a sensation of something like a ball ris- 
ing in the oesophagus, which seemed to extend up as far as 
the top of the sternum, as if propelled by a gradual tonic con- 
traction of the stomach. At quarter past 10, vomiting com- 
menced. This was attended with very little inconvenience 
at first, but after continuing a short time became more severe, 
the ejections consisting principally of bile; together with the 
vomiting, there was much ineffectual retching; almost con- 
stant hiccough; chilliness; dimness of sight; vertigo; inability 
to control the voluntary muscles; distress at the stomach; 
pulse small and creeping, and 34 in a minute; the ordinary 
frequency ranging from 56 to 58. As these symptoms were 
becoming more aggravated, he took Jss. of laudanum, and 
went to bed scarcely able to walk. In ten or fifteen minutes 
the laudanum was repeated, which soon produced sleep. In 
the morning was apparently in better health than he had 
been for several months. At 7 the same morning, three 
grains more were taken; at 9 complained of a confused sensa- 
tion in the head, and almost an entire loss of power of the gas- 
trocnemii muscles. At 12 M. three grains more were taken, 
